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One Step Loperamide capsules are for the relief of sudden diarrhoea (diarrhoea) and help limit trips to the toilet.
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Loperamide is an antidiarrheal (antidiarrheal) medication used to control acute (sudden) diarrhoea it works by slowing the movement of bowel content so you can get on with your day. Diarrhoea can start quite suddenly but doesn’t usually last for many days. Diarrhoea is usually caused by a viral or bacterial infection, food poisoning or foreign travel.
It is important that you read and fully understand the Patient Information Leaflet before purchasing this item.
How to use
Do not take this medicine if:
Talk to your doctor or pharmacist before taking this medicine if:
If you have AIDS and your stomach becomes swollen, stop taking the capsules immediately and contact your doctor.
Usage
Always take this medicine exactly as described in this leaflet or as your doctor or pharmacist have told you. Check with your doctor or pharmacist if you are not sure.
Adults, the elderly and children over 12 years
How to take: The capsules should be swallowed whole with a drink of water.
Dose and how often to take:
After the first loose stool (bowel motion) take 2 capsules with water. After each further loose stool, take 1 capsule.
If you take more medicine than you should, contact your doctor or nearest Accident
and Emergency department taking this leaflet with you.
If you forget to take this medicine
You should only take this medicine as you need it, following the dosage instructions above carefully. If you forget to take a dose, take a dose after the next loose stool (bowel movement).
Do not take a double dose.
Swallow each tablet with plenty of water.
What Loperamide Capsules contain:
Active ingredient:
Loperamide Hydrochloride 2mg
Other ingredients:
Lactose, Maize Starch, Talc, Magnesium Stearate, Gelatin, Quinoline Yellow (E104), Erythrosine
(E127), Patent Blue (E131) and Titanium Dioxide (E171).
Other medicines and this medicine
Tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines including medicines obtained without prescription and especially:
Ritonavir (used to treat HIV)
Quinidine (used to treat abnormal heart rhythms or malaria)
Oral desmopressin (used to treat excessive urination)
Itraconazole or ketoconazole (used to treat fungal infections)
Gemfibrozil (used to treat high cholesterol).
Pregnancy or breast-feeding
Driving and using machines
This medicine may make you feel dizzy, tired or sleepy. You may feel less alert, feel faint or pass out. If you are affected do not drive or use machines.
This medicine contains lactose
The capsules contain lactose; if you have been told by your doctor that you have
an intolerance to some sugars, contact your doctor before taking this medicine.
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Serious side effects
Rare: (may affect up to 1 in 1,000 people)
Stop taking this medicine and see your doctor immediately if you experience any of these serious
side effects:
Other side effects
Common: (may affect up to 1 in 10 people)
Uncommon: (may affect up to 1 in 100 people)
Rare: (may affect up to 1 in 1,000 people)
Special warnings and precautions for use
Treatment of diarrhoea with loperamide hydrochloride is only symptomatic. Whenever an underlying etiology can be determined, specific treatment should be given when appropriate.
Cardiac events including QT interval and QRS complex prolongation and torsades de pointes have been reported in association with overdose. Some cases had a fatal outcome .
Overdose can unmask existing Brugada syndrome. Patients should not exceed the recommended dose and/or the recommended duration of treatment.
The priority in acute diarrhoea is the prevention or reversal of fluid and electrolyte depletion. This is particularly important in young children and in frail and elderly patients with acute diarrhoea. Use of this medicine does not preclude the administration of appropriate fluid and electrolyte replacement therapy.
Since persistent diarrhoea can be an indicator of potentially more serious conditions, this medicine should not be used for prolonged periods until the underlying cause of the diarrhoea has been investigated.
In acute diarrhoea, if clinical improvement is not observed within 48 hours, the administration of loperamide hydrochloride should be discontinued and patients should be advised to consult their doctor.
Patients with AIDS treated with loperamide for diarrhoea should have therapy stopped at the earliest signs of abdominal distension. There have been isolated reports of obstipation with an increased risk for toxic megacolon in AIDS patients with infectious colitis (viral or bacterial pathogens) treated with loperamide hydrochloride.
Although no pharmacokinetic data are available in patients with hepatic impairment, this medicine should be used with caution in such patients because of first pass metabolism as it may result in a Strides Pharma UK Ltd. Loritax 2mg Capsules, Loperamide 2mg Capsules, PL 13606/0184, relative over dosage leading to CNS toxicity
Symptoms:
In case of overdose (including relative overdose due to hepatic dysfunction), CNS depression (stupor, coordination abnormality, somnolence, miosis, muscular hypertonia and respiratory depression), Strides Pharma UK Ltd. Loritax 2mg Capsules ,Loperamide 2mg Capsules, PL 13606/0184, constipation, urinary retention and ileus may occur. Children, and patients with hepatic dysfunction may be more sensitive to CNS effects than adults.
In individuals who have ingested overdoses of loperamide HCl, cardiac events such as QT interval and QRS complex prolongation, torsades de pointes, other serious ventricular arrhythmias, cardiac arrest and syncope have been observed (see section 4.4). Fatal cases have also been reported. Overdose can unmask existing Brugada syndrome.
Treatment:
If symptoms of overdose occur, naloxone can be given as an antidote. Since the duration of action of loperamide is longer than that of naloxone (1 to 3 hours), repeated treatment with naloxone might be indicated. Therefore, the patient should be monitored closely for at least 48 hours in order to detect possible CNS depression.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side
effects not listed here You can also report side effects directly via the Yellow Card Scheme at:
By reporting side affects you can help provide more information on the safety of this product.
Other Information
If you need more advice consult your doctor or pharmacist.
Keep all medicines out of the sight and reach of children.
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